--- The film was conceived and shot in less than a day.
--- The film was originally supposed to be rotorscoped (Shot with live actors, and then animated on top of it), but after animating half of the trailer for Manuscript, Tom realized that it looked really bad, and eliminated the whole process and decided to edit and release it as a live-action movie.
--- The director and the agent in the movie are brothers, hinted by the line "Hey, bro, it's me, Rick" at the beginning of the movie. Tom and John, the actors of the movie, are brothers in real life.
--- The Manuscript project was started when the director wanted to make a short movie to test out a new camcorder he had bought for an upcoming feature film project.
--- The film was shot a day after Christmas.
--- The film was shot without a script or story, while the director had ideas in his mind, he did not write them down since he didn't have time to plan the project and shoot it before he went back to Columbus. The only written lines in the movie was the voicemail monologue, which was written and read at the actor's request. The actor's lines were improvised. The director would let them know of what he would like them to say, and then practice it with them a few times until they got a delivery that he liked.
--- The shower scene was originally a second or so longer than the one shown in the movie, while originally there in the first cut, the director decided to cut it out due to brief nudity.
--- Shooting had to be stopped several times due to the fact that the director had to think of the next scenes and lines before continuing to shoot again.
--- The original ending had the main character sitting in a playground, with empty slides behind him, yet due to the fact that there were kids playing on it when they went to shoot it, the director opted to shoot it on the stairs of the elementary school nearby instead.
--- The voicemail was originally planned to be a holographic video mail which showed up in any glass surface in the rotorscope version. The holographic idea was dropped once the film wasn't going to be rotorscoped. The director had the actor film the entire voicemail monologue while looking at the camera.
--- While originally planned as a two-man project, similar to the director's previous film, Whisper, a third person was later added on to provide the picture and voice of Janet. While actress share the same last name, Lin, as both Tom and John, she is not related to them.